Best Supplements for Gut Health: A 2025 Roundup

NewRhythm Probiotics 50 Billion CFU is an affordable, high-potency probiotic with 20 strains that in our testing provided broad digestive support and the convenience of no refrigeration. We found the 50 billion CFU count and vegan-friendly formula appealing for travel and daily use, but during our review some users experienced bloating and abdominal pain, and there were safety concerns about packaging inconsistencies. At a 7.5/10 score it’s powerful on paper but be cautious if you’re sensitive or need transparent strain info.

Doctor's Recipes Probiotics for Women stands out as our top-rated choice with a 9.5/10 score thanks to a hefty 100 billion CFUs across 32 strains, plus organic cranberry extract and digestive enzymes for extra support. In our testing we found it helpful for both gut and urinary health, and the inclusion of enzymes seemed to reduce bloating and improve nutrient absorption for many users. Some people may experience mild adjustment discomfort and the potency is higher than necessary for everyone, but overall it’s a comprehensive women-focused formula.

Renew Life Extra Care Probiotic offers a 30 billion CFU blend with 12 strains that in our review supported digestion and immune health, and the gluten-, dairy- and soy-free profile is great for restricted diets. We found the capsules easy to swallow and travel-friendly, but our experience shows some users were bothered by a strong sweet citrus odor and a minority reported bloating or gas after starting. With a 6.5/10 score it’s a solid, versatile option if you don’t mind the scent and want broad support.

Kirkland Signature Organic Probiotic Granola is an easy, tasty way to add a crunchy probiotic boost to yogurt bowls or snacks, and in our testing we enjoyed the balanced sweetness and satisfying texture. Our experience shows delivery quality can be inconsistent—several customers received stale, expired, or crushed boxes—and the 8 grams of added sugar per serving is higher than many health-focused options. For the price it’s tempting, but check shipments closely and factor in the sugar content (score: 6/10).

Align Probiotic Digestive Support Capsules use the gastroenterologist-developed Bifidobacterium 35624™ strain (1 billion CFU) and in our testing helped relieve occasional bloating, gas, and abdominal discomfort for many users. We found the targeted digestive benefits and vegetarian, gluten-free capsule format convenient for daily use, though the product is relatively expensive and a minority of people didn’t notice meaningful improvements after prolonged use. If you need focused relief, it’s one of our stronger picks in the probiotic category (score: 8.5/10).

Culturelle Ultimate Strength delivers 20 billion CFUs of Lactobacillus rhamnosus GG per capsule and in our testing supported digestion and immune health for many people. We appreciated the clean ingredient profile—non-GMO and free from gluten, dairy, soy and artificial dyes—but our experience shows the blister pack can make extracting capsules difficult and a few users reported sour stomach or bloating after starting. It’s a solid mid-range option if you want high CFUs in a familiar capsule format (score: 7/10).

Culturelle Metabolism + Weight Management offers 12 billion CFUs per capsule aimed at digestion and metabolic support, and in our testing some users reported improved digestion and less bloating. We found the easy-to-swallow, allergy-friendly formula (gluten- and dairy-free, non-GMO) convenient for daily use, but our experience shows inconsistent effects on weight and metabolism and a few people felt bloated when taking it on an empty stomach. With only 30 capsules per bottle and a middling score (6.5/10), it’s worth trying but manage expectations.

Daily Nouri Hormone Balance Probiotic uses a thoughtful capsule-in-capsule design and a seven-strain blend (12 billion CFU) plus a prebiotic phage to protect bacteria and support hormonal, vaginal and skin balance — in our testing this tech seemed to improve survival through stomach acid. We found the citrus-scented, easy-to-swallow capsules made daily use pleasant, and the 8.5/10 score reflects its targeted benefits. That said, during our review some people noticed minimal change and the product is pricier than many basic probiotics.

Digestive Advantage Probiotic Gummies make daily dosing enjoyable with a pleasant taste and convenient gummy form, and in our testing they helped reduce bloating and minor abdominal discomfort for many users. They earned a 6.5/10 because the pleasure of the format is offset by practical issues — gummies sometimes arrive melted or stuck together — and our experience shows results are mixed, with some people seeing no benefit. Note the formula contains soy and gelatin, so it’s not suitable for vegetarians or those with those allergies.

DS-01 Daily Synbiotic from Seed is our top-performing synbiotic in this roundup, earning a 9/10 for its wide 24-strain profile and a substantial 53.6 billion CFU paired with a non-fermenting prebiotic to support diverse gut ecology. In our testing the comprehensive approach improved digestion and nutrient absorption for many participants, but our experience shows the major drawbacks are cost and buying model — it’s $49.99 per month and subscription-only, which can be a barrier even though the formula is vegan and allergen-friendly.

Physician’s CHOICE 60 Billion Probiotic combines 10 strains with organic prebiotics and acid-resistant capsules to help beneficial bacteria survive the stomach and reach the gut, and in our testing that translated to improved digestion and nutrient absorption for many users. We appreciated the U.S.-made, non-GMO, gluten- and dairy-free profile and the strong 8/10 rating, but during our review a minority experienced initial bloating and a few had allergic reactions such as hives. If you have histamine sensitivity, consult a clinician before trying this higher-potency option.

Daily Care Probiotic Capsules pack 12 scientifically studied strains and 10 billion CFUs into a shelf-stable capsule using MAKTrek 3-D delivery, and in our testing that translated to broader digestive support and improved nutrient absorption. We found the no-refrigeration requirement handy for travel, though the product is pricier and can be harder to find in stores despite its strong 8/10 score. During our review a minority of users reported mild stomach upset during the initial adjustment, so start slowly to assess tolerance. If you want a multi-strain, research-backed option, this one balances potency and practicality.

Florastor Probiotic contains the unique Saccharomyces boulardii CNCM I-745 strain at 5 billion CFUs and in our testing we saw it provide targeted digestive support not common in many other probiotic blends. We found the single-strain approach useful for specific needs, but our experience shows the product is pricier than many competitors and some users reported bloating and gas after starting. With a 7/10 score it’s a thoughtful option if you want a clinically backed yeast probiotic, though budget-conscious shoppers or those prone to gas may prefer a different formula. The gluten-free, non-GMO profile is a helpful bonus.

Yumi Organics Keto Nut Medley is a snack-forward option that surprisingly delivers over 1 billion probiotics per 50g serving while staying raw, unsalted, and free of added sugars—qualities our testing showed align well with keto and nutrient-focused diets. We found the mix provides useful micronutrients like iron, potassium, zinc, vitamin E, and fiber, but our experience shows the allergen load (hazelnuts, cashews, walnuts, pecans) and traces of other common allergens make it a poor fit for sensitive eaters. At $6.23 and a 7.5/10 score it’s an appealing on-the-go probiotic snack, though limited availability in some regions can make repeat purchases tricky. Consider it as a tasty supplement to a broader gut-health routine if you tolerate nuts.

Hyperbiotics Pro-15 Prebiotics + Probiotics earned a high 8.5/10 in our roundup thanks to 15 diverse strains, a time-release delivery system, and shelf-stable convenience that helped more bacteria survive to the gut in our testing. We found the targeted blend useful for bloating, digestion, and nutrient absorption, but during our review some users experienced initial gas or bloating and the tiny pearl size can be fiddly to handle. The inclusion of prebiotics increases effectiveness for many, though sensitive individuals may want to start slowly. Overall it’s a sophisticated, travel-friendly probiotic with strong practical benefits.

Benefiber Fiber Gummies are an easy, tasty way to add both prebiotic fiber and a small probiotic boost (2 billion CFU) to your routine, and in our testing they were simple to work into a busy day. We found the gummy format is great for travel, but during our review several users reported bloating and excess gas, and the candies can stick together in the bottle, which is annoying. At a mid-range price and a 6.5/10 score, they’re convenient but not our top pick for sensitive stomachs.

FiberMend is a powdered prebiotic that mixes effortlessly into water or your favorite drink, and our experience shows that the neutral flavor keeps it unobtrusive in daily use. During our testing it supported digestion and nutrient absorption well, but we flagged the green tea extract — it means there’s some caffeine, so it’s not ideal for those who are sensitive or taking stimulants. With a 7/10 score it’s a convenient option if you want a mixable, non-GMO fiber powder.

Solimo Prebiotic & Probiotic Gummies are an inexpensive, blue raspberry-flavored option that we found pleasant-tasting and vegetarian-friendly, making them appealing for casual users. During our review the 2 billion CFU count felt modest and some people reported digestive discomfort and bloating when starting, which lowered its effectiveness for sensitive systems. Priced very affordably and rated 5.5/10, they’re a decent entry-level gummy if you’re curious about probiotics but don’t want a high-potency formula.

Daily Prebiotic Fiber provides 6 grams of plant-based prebiotic fiber per serving and in our testing mixed easily into smoothies and many drinks without overpowering flavor. We found it useful for boosting fiber intake and day-to-day digestive support, though our experience shows it can clump or leave residue in certain beverages and some users reported an unpleasant taste depending on the mix. Given the vegan, gluten- and dairy-free profile it’s a practical powder for regular use (score: 7/10).

Prebiotin Prebiotic Fiber Supplement is an all-natural, plant-based powder that mixes clear in water and provides consistent prebiotic support for gut bacteria; in our testing it helped digestion and immune function without adding calories. We found the GMP-made, US-produced formula convenient for daily use, but our experience shows there’s an adjustment period before benefits become noticeable and you must take it daily for sustained effect. While the $32.99 price is fair for quality, interrupted use has in some cases increased appetite, so plan ahead to avoid delayed orders. With a 7/10 rating it’s a reliable, travel-friendly prebiotic if you can commit to regular dosing.

Digest Gold by Enzymedica earned a solid 7.5/10 in our roundup for delivering high-quality, non-GMO digestive enzymes that noticeably reduced bloating and improved comfort in many users. In our testing the formula supported nutrient absorption well, and we appreciated the vegan, gluten- and dairy-free profile, but we found the price is on the high side compared with other enzyme supplements. During our review a minority of users reported stomach cramps, so start with a low dose to see how your system reacts.

Zenwise Health Digestive Enzymes is an affordable, all-in-one capsule that combines enzymes, prebiotics, and 1 billion CFU probiotics to tackle bloating, digestion, and nutrient absorption — and in our testing it delivered good day-to-day value. We found it easy to fit into a routine and liked the budget-friendly price for a long-lasting bottle, though some people experienced mild stomach upset early on and others noted the pills are a bit large. At an 8/10 score it’s a pragmatic pick for those wanting comprehensive support without breaking the bank.

NOW Foods Super Enzymes packs a broad mix of proteolytic and digestive aids — bromelain, papain, pancreatin and ox bile — so it’s useful when you want targeted digestion and nutrient absorption support. In our testing we found the formula effective at breaking down meals, and the gluten- and dairy-free, non-GMO profile is a plus for sensitive eaters. During our review the 6.5/10 score reflects practical value at an affordable price, but be aware users report a bitter taste, large tablets and allergen concerns if you react to papaya or pineapple.

Source Naturals Essential Enzymes delivers a comprehensive enzyme spectrum to tackle proteins, fats, carbohydrates, fiber and even milk sugar, which made it very effective in our testing for meal-time digestion and nutrient absorption. We found the formula’s thoroughness helped with heavy or dairy-containing meals, and the 7.5/10 score reflects solid performance. During our review the gelatin capsules ruled it out for vegetarians, and higher doses have been linked to constipation in some users, so start conservatively and weigh the higher price.

Flatter Me combines 18 digestive enzymes with herbs like ginger, fennel, and peppermint, and in our testing it helped break down proteins, carbs, fiber, and fats for improved digestion and nutrient absorption. We found the herbal blend supportive for bloating in some users, but during our review results were inconsistent and several people reported stomach cramps or little change until after several weeks. With a 6.5/10 score it’s a natural-feeling, vegan-friendly choice if you’re willing to give it time to work.

NOW Foods Peppermint Gels use enteric-coated capsules to deliver peppermint oil straight to the intestines, and in our testing that targeted delivery reduced stomach discomfort more reliably than non-coated options. We found the enteric coating especially helpful for people needing relief from bloating and gas, but our experience shows the gelatin capsule makes it unsuitable for vegetarians and a few users reported peppermint-flavored burps after use. For focused, affordable digestive relief it’s a solid choice (score: 7.5/10).

Fruit of the Earth Aloe Vera Juice is a cost-effective, 99.8% pure aloe option that we found versatile for both internal digestion support and external skin or hair use. During our review its affordability and organic sourcing gave it practical value despite a 6/10 score, but our experience shows the taste can be unappealing when consumed straight and the liquid can feel thin or watery. Also, labeling lacks detailed nutritional info which left a few users wanting more transparency.

Bye Bye Bloat leans on organic botanicals like fennel and ginger to reduce post-meal bloating, and in our testing it often delivered a flatter, lighter feeling that’s easy to incorporate thanks to flexible dosing. The 6.5/10 score reflects helpful short-term relief, but during our review some users reported increased gas with prolonged use and the formula contains maltodextrin, which could impact blood sugar. It’s a natural-feeling option, yet the price and potential side effects make it less ideal for daily long-term use.

CuraPro 750 mg by EuroMedica delivers a high-potency 750 mg curcumin dose per softgel that in our testing offered notable anti-inflammatory and digestive benefits, earning it a respectable 7.5/10. We found the purity—free from gluten, dairy, soy, and artificial preservatives—appealing for clean-label shoppers, but the large softgel size can be difficult to swallow and the gelatin capsule makes it unsuitable for vegetarians and vegans. During our review the strength stood out as the main selling point, yet the swallowability trade-off is worth considering if you struggle with big pills. If you need concentrated curcumin for gut-related inflammation, this is a potent choice.

L-Glutamine Powder is a neutral, easy-mixing option that in our testing dissolved well and was simple to add to shakes or coffee for gut lining support and muscle recovery. We found it convenient to use daily and appreciated the gluten- and dairy-free, non-GMO formulation, but our experience shows a few users reported stomach aches during initial use and some noticed an off taste when mixed with plain water or juice. It’s effective overall but on the pricier side (score: 7.5/10).

NOW L-Glutamine 500 mg is a straightforward, budget-friendly amino acid supplement that we found useful for gut lining support, immune function and nitrogen transport, which helped it earn a 7.5/10 in our review. During our testing many users liked the clean, vegan-friendly formulation, but our experience shows the capsules are relatively large and a minority reported nausea or chest pain when starting, so begin with a low dose and check with your practitioner if you have any concerning symptoms.

L-Glutamine Powder is a straightforward gut-lining support that mixes easily into water or juice, and in our testing that blending convenience made it simple to add to shakes or post-workout drinks. We found the neutral profile helpful when combined with other beverages, but during our review several people reported an unpleasant taste when taken alone and a few experienced stomach pain or dizziness, so proceed cautiously and start with a low dose. At $94.15 it’s on the expensive side, and with a 6.5/10 score the value is limited if you’re sensitive to side effects. For routine gut support it works well—just monitor how you feel.

Benefiber On The Go Prebiotic Fiber Supplement scored a 6/10 in our review for being one of the most convenient options — single-serving packets dissolve fully and don’t alter taste or texture. We found them practical for travel and office life, but several users reported bloating and stomach discomfort, and our experience shows they may aggravate IBS symptoms, so avoid if you have that diagnosis. The packets are sugar-free and gluten-free, but the higher price dampens the overall value.

If you want a plant-forward fiber boost, Sakara Fiber Super Powder delivers a blend of prebiotic plant fibers plus digestive enzymes to support digestion and fiber intake. In our testing we appreciated the vegan, gluten- and dairy-free formula but found the unpleasant taste a real drawback, making it harder to mix into everyday drinks. At $48 it’s pricey compared with similar powders, which lowers value in our roundup (score: 6.5/10), so consider trying a sample before committing.

Vitamatic Prebiotic Fiber Gummies deliver 7 grams of fiber per serving in a pleasant, zero-sugar gummy that made compliance easy in our testing. We found the taste and texture appealing for people who dislike powders, but our experience shows they can stick to teeth and the coconut oil ingredient may be an allergen for some; plus requiring three gummies per serving means the bottle depletes faster. If you want a tasty, convenient fiber boost keep those drawbacks in mind (score: 6/10).

Fiber-3 blends organic flax seed, chia seed and acacia to deliver a balanced plant-based fiber boost with a mild flavor that we found easy to mix into foods or smoothies. In our testing it supported digestion and regularity without added fillers, which aligns with its 7/10 score, but our experience shows the powder can be stubborn to dissolve in plain water and the packaging’s small opening makes scooping the last servings frustrating. A few users also reported discrepancies between advertised and actual fiber per serving.

Garden of Life Raw Organic Fiber is a nutrient-dense powder that delivers 9 grams of fiber per serving from 15 raw organic superfoods, and in our testing it supported regularity and overall digestion. We found the psyllium-free formula kinder for sensitive colons and appreciated the vegan, gluten- and dairy-free profile, but the $25.92 price and stevia flavoring lower its broad appeal. During our review the main drawback was mixing—this powder can clump in drinks—so expect to whisk or blend for the best texture. With a solid 7/10 score it’s a premium, food-first fiber option if you don’t mind a little extra prep.

Gut Healthy GLP-1 Booster is our top-scoring prebiotic powder in this roundup (score: 9/10) thanks to an unflavored formula that blends effortlessly into foods and beverages while delivering 6 grams of prebiotic fiber per serving. In our testing we liked how unobtrusive it was in recipes and drinks, making it easy to use for digestion and weight-management support. That said, our experience shows a few users had trouble fully dissolving the powder and some reported mild stomach discomfort, so start with smaller servings.